Does clopidogrel (ISCOVER, PLAVIX) worsen psoriasis? A 70-year old man took clopidogrel (ISCOVER, PLAVIX) in addition to his cardiac medication. Three and a half weeks later, his pre-existing psoriasis worsened. It improved, when he stopped the platelet aggregation inhibitor (NETWORK report 14.438). A few months later, it flared up again with acetylsalicylic acid (ASPIRIN etc.) (14.392). A 68-year old woman had a similar experience after taking clopidogrel and captopril (TENSOBON etc.) for two weeks. She needed treatment because of an exacerbation of her previously stable psoriasis. When the eruption had subsided after stopping both drugs and with specific therapy, re-exposure to clopidogrel was attempted because of existing intolerance of acetylsalicylic acid. Within one day, the psoriasis worsened again. Clopidogrel has to be listed as one of the drugs that can trigger or worsen psoriasis (MEISSNER, M. et al.: Br. J. Dermatol. 2006; 155: 630-1). In remitting relapsing course a recent deterioration may sometimes not be linked to drug therapy. However, improvement after stopping or relapse on re-exposure provides evidence of an association. If this is suspected, please send a report to our NETWORK OF MUTUAL INFORMATION.